Rachel Neuwirth Selected Research

sapanisertib

1/2022	Sapanisertib plus Fulvestrant in Postmenopausal Women with Estrogen Receptor-Positive/HER2-Negative Advanced Breast Cancer after Progression on Aromatase Inhibitor.
1/2021	Sapanisertib Plus Exemestane or Fulvestrant in Women with Hormone Receptor-Positive/HER2-Negative Advanced or Metastatic Breast Cancer.
1/2018	Phase I study of the investigational oral mTORC1/2 inhibitor sapanisertib (TAK-228): tolerability and food effects of a milled formulation in patients with advanced solid tumours.
6/2016	TAK-228 (formerly MLN0128), an investigational oral dual TORC1/2 inhibitor: A phase I dose escalation study in patients with relapsed or refractory multiple myeloma, non-Hodgkin lymphoma, or Waldenström's macroglobulinemia.

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Rachel Neuwirth Research Topics

Disease

10	Multiple Myeloma 01/2017 - 09/2007
8	Neoplasms (Cancer) 01/2018 - 01/2009
3	Peripheral Nervous System Diseases (PNS Diseases) 01/2017 - 01/2010
2	Nausea 01/2022 - 06/2016
2	Breast Neoplasms (Breast Cancer) 01/2022 - 01/2021
2	Vomiting 01/2022 - 06/2016
2	Inflammation (Inflammations) 01/2017 - 06/2016
2	Thrombocytopenia (Thrombopenia) 06/2016 - 09/2014
2	Non-Hodgkin Lymphoma (Lymphosarcoma) 06/2016 - 10/2013
2	Neutropenia 06/2016 - 09/2014
2	Herpes Zoster 10/2013 - 10/2008
1	Hyperglycemia 01/2022
1	Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse) 11/2017
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2017
1	Leukemia 01/2017
1	Diarrhea 01/2017
1	Dermatitis 01/2017
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 01/2017
1	Stomatitis 06/2016
1	Urticaria (Hives) 06/2016
1	Waldenstrom Macroglobulinemia (Macroglobulinemia) 06/2016
1	Fatigue 06/2016
1	Asthenia 06/2016
1	Exanthema (Rash) 06/2016
1	Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular) 09/2014
1	Lymphopenia (Lymphocytopenia) 09/2014
1	Lymphoma (Lymphomas) 09/2014
1	Neoplasm Metastasis (Metastasis) 08/2014
1	Prostatic Neoplasms (Prostate Cancer) 08/2014
1	Mantle-Cell Lymphoma (Lymphoma, Mantle Cell) 10/2013
1	Liver Diseases (Liver Disease) 05/2012
1	Testicular Neoplasms (Testicular Cancer) 11/2011

Drug/Important Bio-Agent (IBA)

16	Bortezomib (Velcade)FDA Link 11/2017 - 09/2007
4	sapanisertibIBA 01/2022 - 06/2016
4	Pharmaceutical PreparationsIBA 01/2017 - 01/2009
3	Prednisone (Sone)FDA LinkGeneric 11/2017 - 01/2010
3	Dexamethasone (Maxidex)FDA LinkGeneric 01/2017 - 10/2008
2	Fulvestrant (Faslodex)FDA Link 01/2022 - 01/2021
2	Mechanistic Target of Rapamycin Complex 1IBA 01/2018 - 06/2016
2	Vincristine (Oncovin)FDA LinkGeneric 11/2017 - 09/2014
2	Cyclophosphamide (Cytoxan)FDA LinkGeneric 11/2017 - 09/2014
2	Rituximab (Mabthera)FDA Link 11/2017 - 09/2014
2	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2017 - 09/2014
1	Estrogen ReceptorsIBA 01/2022
1	Aromatase InhibitorsIBA 01/2022
1	exemestane (Aromasin)FDA Link 01/2021
1	Everolimus FDA Link 01/2021
1	Hormones (Hormone)IBA 01/2021
1	Phosphotransferases (Kinase)IBA 01/2021
1	TAK 733IBA 01/2017
1	Proteasome InhibitorsIBA 01/2017
1	Creatine Kinase (Creatine Phosphokinase)IBA 01/2017
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 01/2017
1	CreatinineIBA 06/2016
1	Gonadotropin-Releasing Hormone (GnRH)FDA Link 08/2014
1	LigandsIBA 08/2014
1	GonadotropinsIBA 08/2014
1	Testosterone (Sustanon)FDA Link 08/2014
1	acetyl- tyrosyl(46)- hydroxypropyl(47)- threonyl(49)- azaglycyl(51)- methylarginyl(53)- tryptophyl(54)- metastin (46-54)IBA 08/2014
1	GTP-Binding Proteins (G-Protein)IBA 08/2014
1	KisspeptinsIBA 08/2014
1	Proteins (Proteins, Gene)FDA Link 06/2012
1	AntigensIBA 11/2011
1	Melphalan (Alkeran)FDA LinkGeneric 01/2010
1	Cytochrome P-450 CYP3A InhibitorsIBA 01/2009
1	Ketoconazole (Nizoral)FDA LinkGeneric 01/2009
1	Alkaline PhosphataseIBA 09/2007

Therapy/Procedure

4	Therapeutics 01/2022 - 11/2009
2	Drug Therapy (Chemotherapy) 08/2016 - 09/2014
1	Intravenous Administration 01/2017
1	Castration 08/2014
1	Immunotherapy 11/2011
1	Stem Cell Transplantation 01/2010